For example, if the three letter code for (column index, row index, slice index is) ILP, then the origin is at the superior, right, anterior corner of the volume, and therefore the axes run from superior to inferior, from right to left, from anterior to posterior. One of the formats for which a reader is already available in the toolkit is the MetaImage file format. Specify anatomic ordering of the axis.However, and this is the point of this message, in the MetaImage documentation on this page Now if I save this image to ITK MetaImage format (.mha) then the field ITK can handle images of arbitrary dimension. The origin of the image is in the anterior-superior-right corner of the body." The minimal structure of the MetaImage header is the following: NDims 3 DimSize 181 217 181 ElementType METUCHAR ElementSpacing 1.0 1.0 1.0 ElementByteOrderMSB False ElementDataFile brainweb1.raw. View 3D model contours from model/3D view, surface objects and volume. For example, the code ASR means that the X axis corresponds to the anterior-posterior direction, the Y corresponds to the superior-inferior direction, and the Z corresponds to the right-left direction. Floating Point MetaImage DICOM Background 4D image (in Simpleware ScanIP. Each of the three letters in the code is an abbreviation for the direction in the patient coordinate system. The available dataset was split into training (. The experimental design is shown in Figure 1. The final PPK model was demonstrated to be suitable and effective and it can be used to evaluate the pharmacokinetic parameters of MHD in Chinese patients with epilepsy and to choose an optimal dosage regimen of oxcarbazepine on the basis of these parameters.Įpilepsy MHD Oxcarbazepine Population pharmacokinetics."RAI codes let you specify image orientation quickly. The MHD images were used for DL model training and data analysis. The MHD clearance was dependent on ALT and gender as follows: CL = tvCL × (ALT/30)(0.181) × (gender) × 1.083 × e (ηCL). BUN and HGB influenced the MHD volume of distribution according to the following equation: V = tvV × (BUN/4.76)(-0.007) × (HGB/140)(-0.001) × e (ηV). The mean values of volume of distribution and clearance of MHD in the patients were 14.2 L and 2.38 L h(-1), respectively. Bootstrap and data splitting were used simultaneously to validate the final PPK models. The effect of age, gender, red blood cell count, red blood cell specific volume, hemoglobin (HGB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), and serum creatine were analyzed. MHD pharmacokinetics obeys a one-compartment model with first-order absorption and elimination. The PPK model for MHD was developed using Phoenix NLME 1.2 with a non-linear mixed-effect model. Patients' clinical data were retrospectively collected. The pharmacologically active metabolite 10,11-dihydro-10-hydrocarbamazepine (MHD) was used as the analytical target for monitoring therapy of oxcarbazepine. A total of 108 oxcarbazepine therapeutic drug monitoring samples from 78 patients with epilepsy were collected in this study. MRIcron - GUI-based visualization and analysis tool for (functional) MRI. The aim of the study was to develop a population pharmacokinetic (PPK) model of oxcarbazepine and optimize the treatment of oxcarbazepine in Chinese patients with epilepsy. MRIConvert - a medical image file conversion utility that converts DICOM files to NIfTI 1.1, Analyze 7.5, SPM99/Analyze, BrainVoyager, and MetaImage volume formats.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |